Memory Matters: What C-suite Executives Must Know About Alzheimer's and Dementia
In Conversation with Dr. Denise Furness
Dr. Denise Furness, a world leader in nutrigenomics and epigenetics, sat down with BlueVerve, to discuss the latest progress in the fight against ageing and its impact on chronic diseases. Both Alzheimer’s and dementia, have had a profound personal impact, driving her mission in her career and research. With over 20 years of experience as a molecular geneticist, numerous awards, and accolades, she shares insights on genetic factors affecting cognitive health and practical steps to mitigate these risks. In this exclusive article, Dr. Furness offers her expert perspective.
Can you briefly introduce yourself and your background?
I’m a geneticist and nutritionist with a focus on nutrigenomics and epigenetics. I hold a PhD in this field and spent 10 years researching gene-diet interactions before transitioning to clinical practice. Now, I use DNA and genetic testing to help my patients optimize their health in various areas, from fertility to healthy aging. Over the last five years, I've focused on reducing the risk of Alzheimer's and dementia, inspired by my personal experience with my mother, who had early-onset dementia. Being genetically predisposed myself, I am passionate about sharing knowledge on how to reduce this risk.
The Role of Genetics in Cognitive Health:
What specific genetic factors influence Alzheimer's and Dementia?
The APOE gene is the strongest genetic risk factor. It’s involved in lipid transportation, particularly to the brain and nervous system. While the APOE3 variant is considered normal, the APOE4 variant significantly increases the risk of Alzheimer’s, dementia, and cardiovascular disease.
Understanding Cholesterol’s Connection:
How does cholesterol affect the risk of Alzheimer's and Dementia?
Given the modern diet, especially in high pressured environments and disrupted schedules, it is important to note that high levels of LDL cholesterol, are strongly associated with an increased risk of Alzheimer's and dementia due to their interaction with the APOE gene. The type of fats consumed is critical; a diet rich in good-quality fats, like Omega-3s, can mitigate these risks, while poor-quality fats from processed foods can exacerbate them. It’s important to understand that food has an essential role in mitigating so many factors in our health and must always be considered as a first step in prevention.
Genetic Testing for C-Suite Executives:
Are there reliable genetic tests available to assess Alzheimer's risk?
While there are no genetic tests that can diagnose Alzheimer's, they can identify risk factors, such as variations in the BDNF gene, which are important for cognitive health. Executives could consider these tests as they can provide valuable insights into their genetic predispositions and help in implementing preventative strategies. The tests are simply another tool to help take ownership and help provide input into the overall roadmap of personalised health management.
Exploring Gene Therapy:
Is research being conducted on genetic-based treatments for Alzheimer's?
Yes, there are ongoing gene therapy studies, particularly involving the BDNF gene. However, while pharmaceutical research is advancing, significant benefits can and should be be derived from lifestyle changes, such as diet and exercise, in managing Alzheimer’s risk.
The Impact on Female Population:
How does menopause influence the risk factors for Alzheimer's in women?
Menopause can significantly elevate the risk of Alzheimer's due to declining estrogen levels, which regulate various genes crucial for brain health, such as PEMT. This can lead to something called choline deficiencies, impacting cognitive function. Addressing these deficiencies early, again through diet and lifestyle modifications can help mitigate risks associated with menopause. Given the growing percentage of women in leadership, it’s imperative for female executives to know the impact and therefore the steps for personal action, when at the highest professional time in their careers.
Proactive Strategies for Aging:
What proactive steps can individuals take to enhance cognitive health and reduce Alzheimer's risk?
Adopting a whole food diet, engaging in regular exercise, managing stress, and maintaining good sleep hygiene are essential strategies. These lifestyle interventions can lower biological age and significantly reduce the risk of Alzheimer’s and other chronic diseases, promoting overall brain health and well-being. And in turn, being at the top of ones game in a progressively industrial time in the executive’s performance driven environment.
Key Takeaways from the Interview with Dr. Denise Furness
- Genetic Risk Factors: The APOE4 variant is the strongest genetic risk factor for Alzheimer’s and dementia, affecting cognitive and cardiovascular health.
- Cholesterol’s Role: High LDL cholesterol is linked to Alzheimer’s risk, while a diet rich in Omega-3s can help mitigate this risk.
- Genetic Testing Value: Genetic tests can identify risk factors, with the BDNF gene being crucial for cognitive health and mood.
- Research Developments: Gene therapy studies, particularly involving BDNF, show promise, but lifestyle interventions remain vital.
- Menopause Impact: Hormonal changes during menopause increase Alzheimer's risk; nutritional and lifestyle changes can help manage it.
- Proactive Health Strategies: Adopting a wholefood diet, regular exercise, stress management, and good sleep hygiene can lower biological age and reduce chronic illness risk.folate or B vitamin intake.
